Think about the space your photography will occupy.  Simple frames allow you to highlight the print while more ornate frames can distract from the photo.  Generally a simple black frame with a white mat tends to highlight a photograph best.

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Make sure your photograph is matted and framed to conservation or museum grade standards.  The quality of materials is important.

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A mat board protects the image inside the frame from moisture damage by keeping your print away from the glass.  If there is no gap and your photograph is up against the glass for too long, moisture can build up and cause your photo to stick to the glass.  It's best to use Conservation Grade (Acid Free & PH Neutral) or Museum Grade (100% Cotton Fiber) for matting.  Mat boards come in single and double.

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When using a back board for framing, make certain that your MDF material doesn't cause damage to your image over the years due to acid levels present.  Foam-core is an acid-free option to preserve works of art, but once a photo is mounted to foamcore, it is irreversible.

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Rather than use standard clear glass or non-reflective glass which have no UV retardant properties, go for UV Clear which blocks 99% UV light.  UV Non-Reflective reduces any glare even further.

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Plexiglass/Acrylic is a lightweight and shatterproof option available in plain, UV protected and non-reflective options.  Lighter in weight, it is more expensive than glass although it can be prone to scatching more easily.